Tel: (613) 549-6666 x 7984 Kidd House, 100 Stuart Street Kingston, ON K7L 3N6
Technology and health care for the elderly medical research studies

Focus on strategic priorities that have significant social impact.

CAT 2015-TG2

Reducing post-discharge potentially inappropriate medications amongst the elderly: a multi-centre electronic deprescribing intervention

This 16-week pilot study will evaluate the impact of MedStopper, a previously developed electronic deprescribing tool, on reduction of potentially inappropriate medications (PIMs) as compared to usual care.

Possible Research Results

Anticipated findingsWe anticipate that MedStopper will reduce inappropriate medication use and that results from this preliminary study will help us to adapt the tool for a larger national study powered to reduce adverse drug events.

Impact of findingsFindings could be the first step to incorporating deprescribing as a part of standard care upon discharge from hospital. These findings should inform best practices in frail elderly patients with polypharmacy and ultimately decrease the burden and cost of potentially inappropriate medications and their associated complications. If successful, this could lead to a reduction of several thousand hospitalizations annually, across Canada.

About the Project

Polypharmacy, or the concomitant use of five or more drugs, is a serious health concern affecting more than half of Canadians aged 65 years and older. Medications can be essential, but each additional one increases the risk of an adverse drug event (ADE). Polypharmacy is the number one identifiable risk factor for ADEs and Canada's 1.1 million frail older adults are especially at risk. ADEs are responsible for nearly 27,000 hospital admissions annually in Canada and up to 20% of return visits to the hospital within 30 days of discharge. Many ADEs could be preventable or ameliorable through interventions to reduce inappropriate prescribing.

Our intervention will adapt MedStopper in order to automate the process of deprescribing. At the time of hospitalization, the patient's medications and comorbidities, along with a measure of frailty, will be entered into MedStopper, which will generate an individualized, prioritized, deprescription plan targeting PIMs. The most responsible physician could then choose to implement the deprescribing plan after discussion with the patient/caregiver.

For more details on the project rationale, hypothesis, objectives and research plan, click here.

Project Team

Principal Investigators:

Todd Campbell Lee, MD, MPH, FRCPC -- McGill University Health Centre

Emily McDonald, MD, MSc -- McGill University Health Centre


James Downar, MDCM, MHSc, FRCPC -- Toronto General Hospital, University Health Network

Alan Forster, MD, MSc, FRCPC -- Ottawa Hospital

Allen Huang, MDCM, FACP, FRCPC -- Ottawa Hospital

Louise Pilote, MD, PhD, MPH -- McGill University

Robyn Tamblyn, PhD -- McGill University

Knowledge Users and Partners:

Janice Carr, PharmD

Project Contact: Todd Lee --

CAT 2015-TG2