Screening Elderly PatieNts For InclusiOn in a Weaning Trial: The SENIOR Trial
The aim of the trial is to assess metrics that reflect our ability to consent, enroll and recruit elderly and very elderly invasively ventilated patients and evaluate adherence to the study protocols in preparation for conducting a large weaning trial.
Project findings and information will be updated on a continual basis.
About the Project
Weaning is the process of transferring the work of breathing from the ventilator back to the patient. Approximately 40% of the total time spent on mechanical ventilation is dedicated to weaning. Research supports that the use of specific strategies to wean patients including the use of daily screening (to identify patients who can breathe spontaneously) and the conduct of tests of patient’s ability to breathe spontaneously to limit the time spent on ventilators and improve outcomes. No randomized trial has evaluated the optimal screening frequency to identify patients to undergo a spontaneous breathing trial (SBT) and no weaning trial has ever been conducted in elderly patients.
The SENIOR Trial will be the first weaning trial conducted in the elderly. This trial is also novel in (1) evaluating our ability to recruit elderly critically ill patients into a mechanical ventilation trial, (2) assessing whether protocols can be adhered to similarily in both study arms and (3) obtaining preliminary estimates of differences in important clinical outcomes between elderly and very elderly participants. This trial will provide valuable information to better inform discussions with elderly, critically ill patients and their SDMs regarding weaning outcomes.
For more details on the project rationale, objectives and research plan, click here.
Karen Burns, MD, MSc, FRCPC -- St. Michael's Hospital/University of Toronto
Laurent Brochard, MD -- St. Michael's Hospital
Deborah Cook, MD, MSc -- St. Joseph's Hospital, Hamilton
Peter Dodek, MD, MHSc -- St. Paul's Hospital, Vancouver
Eddy Fan, MD, MPH, BSc -- Toronto General Hospital
Jan Friedrich, MD, MSc, D.Phil, BSc -- St. Michael's Hospital
Lori Hand, RRT -- Hamilton General Hospital
Michelle Kho, PhD, PT -- St. Joseph's Hospital
François Lamontagne, MD, MSc -- Université de Sherbrooke
Maureen Meade, MD, MSc -- McMaster University
Sangeeta Mehta, MD, BSc -- Mount Sinai Hospital, Toronto
Andrew Seely, MD, PhD -- Ottawa General Hospital
Project Contact: Leena Rizvi -- email@example.com
Key words: weaning; spontaneous breathing; mechanical ventilation; randomized trial; outcomes