A New Approach to Evaluating Frailty in Solid Organ Transplantation
The results of this study will help transplant programs better predict benefit from organ transplantation, will improve our understanding of the aging process and how it is affected by transplantation and may lead to strategies to reduce frailty and improve the medical care of older individuals with advanced organ failure.
Project findings and information will be updated on a continual basis.
About the Project
Solid organ transplantation is a life-saving treatment for people with organ failure, but organ donors and recipients must be chosen carefully since transplants are risky and donor organs are so scarce. In recent years, transplant programs have been accepting older donors and recipients with more chronic health problems. It is possible that some of these patients are living with frailty, which may lead to poor outcomes after transplantation. Prior to this study, we did not know how best to measure frailty in organ transplant candidates and recipients. Without appropriate tools to measure frailty, we do not know if patients living with frailty got as much benefit from transplantation as individuals not living with frailty, or how to help patients living with frailty with organ failure have longer and better lives before and after transplantation though exercise or other treatments.
The objective of this study was to develop and test the usefulness of a new tool to measure frailty in transplant candidates for heart, lung, kidney or liver transplantation. Using the cumulative deficits model, we determined that increasing frailty is associated with less likelihood of transplant listing and higher risks for transplant waitlist death or delisting and post-transplant death.
Lianne Singer, MD, FRCPC — University Health Network
Susan Abbey, MD, FRCPC — University Health Network
Sang Joseph Kim, MD, PhD, FRCPC — University Health Network
Jane MacIver, RN(NP), PhD — University Health Network
Sunita Mathur, PT, PhD — University of Toronto
Eberhard Renner, MD — University Health Network
Kenneth Rockwood, MD, FRCPC — Dalhousie University
Heather Ross, MD, MSc, FRCPC — University Health Network
Knowledge Users and Partners:
Multi-Organ Transplant Program, University Health Network
Trillium Gift of Life Network
Project Contact: Lianne Singer — firstname.lastname@example.org