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Technology and health care for the elderly medical research studies
We facilitate evidence-based research, knowledge sharing and clinical practices that improve healthcare outcomes for frail elderly Canadians, their families and caregivers.

Knowledge in action

Recently published papers

Theou O, Blodgett JM, Godin J, Rockwood K. Association between sedentary time and mortality across levels of frailty. CMAJ: August 21, 2017 vol. 189 no. 33 doi: 10.1503/cmaj.161034.

Abstract: Sedentary behaviours are associated with adverse health outcomes in middle-aged and older adults, even among those who exercise. This study examined whether the degree of frailty affects the association between sedentary behaviours and higher risk of mortality. In this prospective cohort study, the study used data from 3141 community-dwelling adults 50 years of age or older from the 2003/04 and 2005/06 cohorts of the US National Health and Nutrition Examination Survey. The study found that the effect of sedentary behaviours on mortality varied by level of frailty. Adults with the highest frailty level experienced the greatest adverse impact. Low frailty levels (frailty index score ≤ 0.1) seemed to eliminate the increased risk of mortality associated with prolonged sitting, even among people who did not meet recommended physical activity guidelines.

Fougère B, Boulanger E,  Nourhashémi F, Guyonnet S, Cesari M. Chronic Inflammation: Accelerator of Biological Aging. The Journals of Gerontology: Series A, Volume 72, Issue 9, 1 September 2017, Pages 1218–1225,

Abstract: Biological aging is characterized by a chronic low-grade inflammation level. This chronic phenomenon has been named “inflamm-aging” and is a highly significant risk factor for morbidity and mortality in the older persons. The most common theories of inflamm-aging include redox stress, mitochondrial dysfunction, glycation, deregulation of the immune system, hormonal changes, epigenetic modifications, and dysfunction telomere attrition. Inflamm-aging plays a role in the initiation and progression of age-related diseases such as type II diabetes, Alzheimer’s disease, cardiovascular disease, frailty, sarcopenia, osteoporosis, and cancer. This review will cover the identification of pathways that control age-related inflammation across multiple systems and its potential causal role in contributing to adverse health outcomes.

Andrew MK, Shinde V, Lingyun Ye S., Hatchette T, Haguinet F, Dos Santos G, McElhaney JE, Ambrose A, Boivin G, Bowie W,Chit A, El Sherif M, Green K, Halperin S, Ibarguchi B, Johnstone J, Katz K, Langley J, Leblanc J, Loeb M, MacKinnon-Cameron D, McCarthy A, McGeer A, Powis J, Richardson D, Semret M, Stiver G, Trottier S, Valiquette L, Webster D, McNeil S for the Serious Outcomes Surveillance Network of the Public Health Agency of Canada/Canadian Institutes of Health Research Influenza Research Network (PCIRN) and the Toronto Invasive Bacterial Diseases Network (TIBDN).The Importance of Frailty in the Assessment of Influenza Vaccine Effectiveness Against Influenza-Related Hospitalization in Elderly People. The Journal of Infectious Diseases, jix282, (published 26 July 2017).

Abstract: Influenza is an important cause of morbidity and mortality among older adults. Even so, effectiveness of influenza vaccine for older adults has been reported to be lower than for younger adults, and the impact of frailty on vaccine effectiveness (VE) and outcomes is uncertain. We aimed to study VE against influenza hospitalization in older adults, focusing on the impact of frailty. This study reported VE of trivalent influenza vaccine (TIV) in people ≥65 years of age hospitalized during the 2011–2012 influenza season using a multicenter, prospective, test-negative case-control design. A validated frailty index (FI) was used to measure frailty. (Clinical Trials Registration: NCT01517191.) Despite commonly held views that VE is poor in older adults, we found that TIV provided good protection against influenza hospitalization in older adults who were not frail, though VE diminished as frailty increased.

Slaughter SE, Bampton E, Erin DF, Ickert C, Wagg AS, Allyson Jones C, Schalm C, Estabrooks, CA. Knowledge translation interventions to sustain direct care provider behaviour change in long-term care: A process evaluation. J Eval Clin Pract. 2017 Jul 10. doi: 10.1111/jep.12784. [Epub ahead of print].

Abstract: Process evaluation can be used to understand the factors influencing the impact of knowledge translation (KT) interventions. The aim of this mixed methods process evaluation was to evaluate the processes and perceived outcomes of eight KT interventions that were used with healthcare aides (HCAs) to introduce a mobility innovation into their daily care practices. The study examined the perceived effectiveness of various KT interventions in sustaining daily performance of the sit-to-stand mobility innovation by HCAs with residents in long-term care. Results: Both HCAs and their leaders perceived reminders, followed by discussion groups, to be the most effective KT interventions to sustain practice change. Healthcare aide champions were deemed least effective by both leaders and HCAs. Leaders identified both the focus group discussion and audit and feedback posters in the study as the most difficult to implement. Participants valued interventions that were strategically visible, helped to clarify misconceptions about the new care innovation, supported teamwork, and made visible the resident benefits of the care innovation. Logistical issues, such as staff scheduling and workload, influenced the perceived feasibility of the various KT interventions. Conclusions: Understanding how care staff in long-term care settings perceive KT interventions can inform the choice of future use of these interventions to move research evidence into practice.

Eamer G, Gibson J, Gillis C, Hsu A, Krawczyk M, MacDonald E, Whitlock R, Khadaroo R. Surgical frailty assessment: a missed opportunity. BMC Anesthesiology, 2017 (17:99).

Muscedere, J. Moving towards standardized data and outcomes for frailty studies. Journal of Frailty & Aging vol. 6, supp 1, 9-10 (July 2017).

Click here to learn more about this CFN-funded research (SIG2014-M1).

Abstract:  Understanding the extent to which current antibiotic prescribing behaviour is influenced by clinicians’ historical patterns of practice will help target interventions to optimize antibiotic use in long-term care. We conducted a retrospective cohort study of all physicians who prescribed to residents in long-term care facilities in Ontario between Jan. 1 and Dec. 31, 2014. We examined variability in antibiotic prescribing among physicians for 3 measures: start of treatment with antibiotics, use of prolonged durations exceeding 7 days and selection of fluoroquinolones. Among 1695 long-term care physicians, who prescribed for 93 132 residents, there was wide variability in the start of antibiotic treatment, use of prolonged treatment durations and selection of fluoroquinolones. After controlling for individual resident characteristics, prior prescribing tendency was a significant predictor of current practice. Physicians prescribing antibiotics exhibited individual, measurable and historical tendencies toward start of antibiotic treatment, use of prolonged treatment duration and class selection. Prescriber audit and feedback may be a promising tool to optimize antibiotic use in long-term care facilities.

Hubbard, R.E., Peel, N,M., Samanta, M., Gray, L.C., Mitnitski, A., Rockwood, K. Age Ageing. 2017 May 22:1-6. Frailty status at admission to hospital predicts multiple adverse outcomes. doi: 10.1093/ageing/afx081. [Epub ahead of print]

Abstract: Frailty is proposed as a summative measure of health status and marker of individual vulnerability. We aimed to investigate the discriminative capacity of a frailty index (FI) derived from interRAI Comprehensive Geriatric Assessment for Acute Care (AC) in relation to multiple adverse inpatient this prospective cohort study, an FI was derived for 1,418 patients ≥70 years across 11 hospitals in Australia. The interRAI-AC was administered at admission and discharge by trained nurses, who also screened patients daily for geriatric syndromes. The interRAI-AC can be used to derive a single score that predicts multiple adverse outcomes in older inpatients. A score of ≤0.40 can well discriminate patients who are unlikely to die or experience a geriatric syndrome. Whether the FI-AC can result in management decisions that improve outcomes requires further study.

Raslan, I.A., McDonald, E.G., Lee, T.C. Missed Opportunities for Deprescription: A Teachable Moment. JAMA Intern Med. Published online May 5, 2017. doi: 10.1001/jamainternmed.2017.1435.

Matlow, J. N., Bronskill, S. E., Gruneir, A., Bell, C. M., Stall, N. M., Herrmann, N., Seitz, D. P., Gill, S. S., Austin, P. C., Fischer, H. D., Fung, K., Wu, W. and Rochon, P. A. (2017), Use of Medications of Questionable Benefit at the End of Life in Nursing Home Residents with Advanced Dementia. J Am Geriatr Soc. doi:10.1111/jgs.14844.

Abstract: The objectives of this study were to determine the prevalence of and resident characteristics associated with the prescription of medications of questionable benefit (MQBs) near the end of life in older adults with advanced dementia in nursing homes. It was a population-based, cross-sectional study using Resident Assessment Instrument (RAI) Minimum Data Set 2.0 linked to health administrative data. Participants were all 9,298 nursing home residents with advanced dementia who died between June 1, 2010, and March 31, 2013; who were aged 66 and older at time of death; and who received at least one MQB in their last year of life. The prevalence of eight classes of MQBs (e.g., lipid-lowering agents, antidementia drugs) used in the last 120 days and last week of life was measured. Conclusion: Many nursing home residents with advanced dementia are dispensed MQBs in the last week of life. Given that MQBs may cause more harm than benefit in this vulnerable population, it is important for physicians to actively reassess the role of all medications toward the end of life.

Laur CV, McNicholl T, Valaitis R, Keller H. Malnutrition or frailty? Overlap and evidence gaps in the diagnosis and treatment of frailty and malnutrition. Applied Physiology, Nutrition, and Metabolism, 2017, 42(5): 449-458, 10.1139/apnm-2016-0652.

Abstract: There is increasing awareness of the detrimental health impact of frailty on older adults and of the high prevalence of malnutrition in this segment of the population. Experts in these 2 arenas need to be cognizant of the overlap in constructs, diagnosis, and treatment of frailty and malnutrition. There is a lack of consensus regarding the definition of malnutrition and how it should be assessed. While there is consensus on the definition of frailty, there is no agreement on how it should be measured. Separate assessment tools exist for both malnutrition and frailty; however, there is intersection between concepts and measures. This narrative review highlights some of the intersections within these screening/assessment tools, including weight loss/decreased body mass, functional capacity, and weakness (handgrip strength). The potential for identification of a minimal set of objective measures to identify, or at least consider risk for both conditions, is proposed. Frailty and malnutrition have also been shown to result in similar negative health outcomes and consequently common treatment strategies have been studied, including oral nutritional supplements. While many of the outcomes of treatment relate to both concepts of frailty and malnutrition, research questions are typically focused on the frailty concept, leading to possible gaps or missed opportunities in understanding the effect of complementary interventions on malnutrition. A better understanding of how these conditions overlap may improve treatment strategies for frail, malnourished, older adults.

Holroyd-Leduc JM, McMillan J, Jette N, Brémault-Phillips SC, Duggleby W, Hanson HM, Parmar J. Stakeholder Meeting: Integrated Knowledge Translation Approach to Address the Caregiver Support GapCan J Aging. 2017 Mar;36(1):108-119. doi: 10.1017/S0714980816000660. Epub 2017 Jan 5.

Abstract: Family caregivers are an integral and increasingly overburdened part of the health care system. There is a gap between what research evidence shows is beneficial to caregivers and what is actually provided. Using an integrated knowledge translation approach, a stakeholder meeting was held among researchers, family caregivers, caregiver associations, clinicians, health care administrators, and policy makers. The objectives of the meeting were to review current research evidence and conduct multi-stakeholder dialogue on the potential gaps, facilitators, and barriers to the provision of caregiver supports. A two-day meeting was attended by 123 individuals. Three target populations of family caregivers were identified for discussion: caregivers of seniors with dementia, caregivers in end-of-life care, and caregivers of frail seniors with complex health needs. The results of this meeting can and are being used to inform the development of implementation research endeavours and policies targeted at providing evidence-informed caregiver supports.

Cesari M, Landi F, Calvani R et al. Rationale for a preliminary operational definition of physical frailty and sarcopenia in the SPRINTT trial. Aging Clin Exp Res (2017) 29: 81. doi:10.1007/s40520-016-0716-1 

Abstract: In the present article, the rationale that guided the operationalization of the theoretical concept of physical frailty and sarcopenia (PF&S), the condition of interest for the “Sarcopenia and Physical Frailty in Older People: Multicomponent Treatment Strategies” (SPRINTT) trial, is presented. In particular, the decisions lead to the choice of the adopted instruments, and the reasons for setting the relevant thresholds are explained. In SPRINTT, the concept of physical frailty is translated with a Short Physical Performance Battery score of ≥3 and ≤9. Concurrently, sarcopenia is defined according to the recent definitions of low muscle mass proposed by the Foundation for the National Institutes of Health—Sarcopenia Project. Given the preventive purpose of SPRINTT, older persons with mobility disability (operationalized as incapacity to complete a 400-m walk test within 15 min; primary outcome of the trial) at the baseline are not included within the diagnostic spectrum of PF&S. 

Cesari M, Pérez-Zepeda MU, Marzetti E. Frailty and Multimorbidity: Different Ways of Thinking about Geriatrics. Impact of home care versus alternative locations of care on elder health outcomes: an overview of systematic reviewsJ Am Med Dir Assoc. 2017 Mar 6. pii: S1525-8610(17)30034-8. doi: 10.1016/j.jamda.2016.12.086. [Epub ahead of print] 

Abstract: The terms multimorbidity and frailty are increasingly used in the medical literature to measure the risk profile of an older individual in order to support clinical decisions and design ad hoc interventions. The construct of multimorbidity was initially developed and used in nongeriatric settings. It generates a monodimensional nosological risk profile, grounding its roots in the somewhat inadequate framework of disease. On the other hand, frailty is a geriatric concept that implies a more exhaustive and comprehensive assessment of the individual and his/her environment, facilitating the implementation of multidimensional and tailored interventions. This article aims to promote among geriatricians the use of terms that may better enhance their background and provide more value to their unrivaled expertise in caring for biologically aged persons.

Boland L, Légaré F, Becerra Perez MM, Menear M, Garvelink MM, McIsaac DI, Guérard GP, Emond J, Brière N, Stacey D. Impact of home care versus alternative locations of care on elder health outcomes: an overview of systematic reviews. BMC Geriatrics, 2017(17:20) DOI: 10.1186/s12877-016-0395-y

Click here to learn more about this CFN-funded research (CORE2013-56).

Abstract: Many elders struggle with the decision to remain at home or to move to an alternative location of care. A person’s location of care can influence health and wellbeing. Healthcare organizations and policy makers are increasingly challenged to better support elders’ dwelling and health care needs. A summary of the evidence that examines home care compared to other care locations can inform decision making. We surveyed and summarized the evidence evaluating the impact of home care versus alternative locations of care on elder health outcomes.

Puts MTE, Toubasi S, Andrew MK, Ashe MC, Ploeg J, Atkinson E, Ayala AP, Roy A, Monforte MR, Bergman H, McGilton K.  Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a scoping review of the literature and international policies. Age Ageing (2017) 46(3): 383-392. DOI:

Abstract: Frailty impacts older adults’ ability to recover from an acute illness, injuries and other stresses. Currently, a systematic synthesis of available interventions to prevent or reduce frailty does not exist. This study was a scoping review of interventions and international policies designed to prevent or reduce the level of frailty in community-dwelling older adults, using the framework of Arksey and O'Malley. Fourteen studies were included: 12 randomised controlled trials and 2 cohort studies (mean number of participants 260 (range 51–610)), with most research conducted in USA and Japan. The study quality was moderate to good. The interventions included physical activity; physical activity combined with nutrition; physical activity plus nutrition plus memory training; home modifications; prehabilitation (physical therapy plus exercise plus home modifications) and comprehensive geriatric assessment (CGA). The review showed that the interventions that significantly reduced the number of frailty markers present or the prevalence of frailty included the physical activity interventions (all types and combinations), and prehabilitation. Nine of the 14 studies reported that the intervention reduced the level of frailty. The results need to be interpreted with caution, as only 14 studies using 6 different definitions of frailty were retained. Future research could combine interventions targeting more frailty markers including cognitive or psychosocial well-being.

Moorhouse P, Theou O, Fay S, McMillan M, Moffat H, Rockwood K. Treatment in a Geriatric Day Hospital improve individualized outcome measures using Goal Attainment Scaling. BMC Geriatrics, 2017(17:9)

Abstract: Evidence regarding outcomes in the Geriatric Day Hospital (GDH) model of care has been largely inconclusive, possibly due to measurement issues. This prospective cohort study aimed to determine whether treatment in a GDH could improve individualized outcome measures using goal attainment scaling (GAS) and whether improvements are maintained 6-months post-discharge.The study demonstrated short- and long-term effectiveness of GDH in helping patients achieve individualized outcome measures using GAS.

Durepos P, Wickson-Griffiths A, Hazzan AA, Kaasalainen S, Vastis V, Battistella L, Papaioannou A. (2017) Assessing palliative care content in Dementia Care Guidelines: A Systematic Review. J Pain Symptom Manage. doi: 10.1016/j.jpainsymman.2016.10.368. Epub 2017 Jan 4. Review. PMID: 28063859.

Abstract: Families of persons with dementia continue to report unmet needs during end of life (EOL). Strategies to improve care and quality of life for persons with dementia include development of clinical practice guidelines (CPGs) and an integrative palliative approach. We aimed to assess palliative care content in dementia CPGs to identify the presence or limitations of recommendations and discussion pertaining to common issues or domains affected by illness as described by the Canadian Hospice Palliative Care Association "Square of Care."A systematic review of databases and gray literature was conducted for recent CPGs. Guidelines meeting inclusion criteria were evaluated using the Appraisal of Guidelines for Research and Evaluation II instrument. Eleven CPGs were selected from 3779 citations and analyzed using illness domains described by the "Canadian Hospice Palliative Care Association Model." Nine guidelines demonstrated the maximum level of content regarding physical, psychological, and social care. Conversely, spiritual care was either absent (three) or minimal (three) in CPGs. Six CPGs did not address loss or grief, and seven CPGs did not address or had minimal content regarding EOL care. The lack of content surrounding grief represents a gap for this population at high risk for complicated grief and chronic sorrow. Results of this review require attention by CPG developers and researchers to develop evidence-based recommendations surrounding spiritual care, EOL, and grief.

Ball I, Bagshaw S, Burns K, Cook D, Day A, Dodek P, Kutsogiannis J, Mehta S, Muscedere J, Stelfox H, Turgeon A, Wells G, Stiell I. Hospital Outcomes of Very Elderly Critically Ill Medical and Surgical Patients: A Multi-Centre Prospective Cohort Study. Canadian Journal of Anaesthesia 64(3) December 2016. DOI: 10.1007/s12630-016-0798-4.

Abstract: Very elderly (over 80 yr of age) critically ill patients admitted to medical-surgical intensive care units (ICUs) have a high incidence of mortality, prolonged hospital length of stay, and dependent living conditions should they survive. The primary purpose of this study was to describe the outcomes and differences in outcomes between very elderly medical patients and their surgical counterparts admitted to Canadian ICUs, thereby informing decision-making for clinicians and substitute decision-makers. Methods: This was a prospective multicentre cohort study of very elderly medical and surgical patients admitted to 22 Canadian academic and non-academic ICUs. Outcome measures included ICU length of stay and mortality, hospital length of stay and mortality, and disposition following hospital discharge. There were 1,671 patients evaluated. Conclusions: In this large sample of critically ill medical and surgical patients, the admission SOFA score and hospital lengths of stay were not different between the two groups, but medical patients had longer ICU lengths of stay and higher ICU and hospital mortality than surgical patients.

Heckman G, Boscart VM, D’Elia T, Kelley ML, Kaasalainen S, McAiney CA, van der Horst M-L, McKelvie RS. Managing Heart Failure in Long-Term Care: Recommendations from an Interprofessional Stakeholder Consultation’, Canadian Journal on Aging / La Revue canadienne du vieillissement 2016;35(4), pp. 447–464. doi: 10.1017/S071498081600043X.

Abstract: Heart failure (HF) affects up to 20 per cent of residents in long-term care (LTC) and is associated with substantial morbidity, mortality, and health service utilization. Our study objective was to formulate recommendations on implementing HF care processes in LTC. A three-phase and iterative stakeholder consultation process, guided by expert panel input, was employed to develop recommendations on implementing care processes for HF in LTC. This article presents the results of the third phase, which consisted of a series of interdisciplinary workshops. We developed 17 recommendations. Key elements of these recommendations focus on improving interprofessional communication and improving HF-related knowledge among all LTC stakeholders. Engaging frontline staff, including personal support workers, was stated as an essential component of all recommendations. System-level recommendations include improving communication between LTC homes and acute care and other external health service providers, and developing facility-wide interventions to reduce dietary sodium intake and increase physical activity.

Heckman GA, Boscart VM, Franco BB, Hillier L, Crutchlow L, Lee L, Molnar F, Seitz D, Stolee P. Quality of Dementia Care in the Community: Identifying Key Quality Assurance Components. Canadian Geriatrics Jounal 2016 Dec;19(4). DOI:

Abstract: Primary care-based memory clinics (PCMCs) have been
established in several jurisdictions to improve the care for
persons with Alzheimer’s disease and related dementias.
We sought to identify key quality indicators (QIs), quality
improvement mechanisms, and potential barriers and facilitators
to the establishment of a quality assurance framework
for PCMCs.

Sawatzky R, Porterfield P, Roberts D, Lee J, Liang L, Reimer-Kirkham S, Pesut B, Schalkwyk T, Stajduhar K, Tayler C, Baumbusch J, Thorne S. Embedding a Palliative Approach in Nursing Care Delivery: An Integrated Knowledge Synthesis. Advances in Nursing Science (2016), online first. doi: 10.1097/ANS.0000000000000163

Abstract: A palliative approach involves adapting and integrating principles and values from palliative care into the care of persons who have life-limiting conditions throughout their illness trajectories. The aim of this research was to determine what approaches to nursing care delivery support the integration of a palliative approach in hospital, residential, and home care settings. The findings substantiate the importance of embedding the values and tenets of a palliative approach into nursing care delivery, the roles that nurses have in working with interdisciplinary teams to integrate a palliative approach, and the need for practice supports to facilitate that embedding and integration.

Giangregorio L, MacIntyre N, Laprade J, McArthur C, Cheung A, Jain R, and Papaioannou A. How to Implement Physical Activity Evidence for your Geriatric Patients with Falls or Fractures: A Case-Based Exercise in Knowledge Translation. Canadian Geriatrics Journal of CME CME Journal 2016 Nov;6(2)

Abstract: We present a case-based approach to applying exercise and physical activity recommendations for individuals at high risk of falls and fractures. The case has a history of falls, and two osteoporotic vertebral fractures. We summarize Too Fit to Fracture “clinical pearls” for geriatrics practice, including advice on assessment, exercise, safe physical activity, and pain management. Best evidence supports the recommendation that older adults should engage in a multicomponent exercise program, including resistance training and challenging balance exercises, in addition to aerobic physical activity. The Too Fit to Fracture recommendations support daily attention to posture, and exercises to improve back extensor strength.

Theou O, Chapman I, Wijeyaratne L, Piantadosi C, Lange K, Naganathan V, Hunter P, Cameron ID, Rockwood K, Visvanathan R. Can an intervention with testosterone and nutritional supplement improve the frailty level of under-nourished older people?. The Journal of Frailty and Aging (JFA) 2016;5(4):247-252.

Abstract: The objective of this study was to examine whether a testosterone and a high calorie nutritional supplement intervention can reduce frailty scores in undernourished older people using multiple frailty tools. Frailty was operationalized using three frailty indices (FI-lab, FI-self-report, FI-combined) and the frailty phenotype. A testosterone and a high calorie nutritional supplement intervention did not improve the frailty levels of under-nourished older people. Even so, when frailty was measured using a frailty index combining self-reported and lab data we found that participants who received the intervention were more likely to show persistent improvement in their frailty scores.

Légaré F, Brière N, Stacey D, Lacroix G, Desroches S, Dumont S, Fraser KD, Rivest L-P, Durand PJ, Turcotte S, Taljaard M, Bourassa H, Roy L, Painchaud Guérard G. Implementing shared decision-making in interprofessional home care teams (the IPSDM-SW study): protocol for a stepped wedge cluster randomised trial . BMJ Open 2016;6:e014023 doi:10.1136/bmjopen-2016-014023. Epub 2016 Nov 24.

Click here to learn more about the CFN-funded research this study is based on (CORE2013-56).

Abstract: The frail elderly in Canada face a tough decision when they start to lose autonomy: whether to stay at home or move to another location. This study seeks to scale up and evaluate the implementation of shared decision-making (SDM) in interprofessional (IP) home care teams caring for elderly clients or their caregivers facing a decision about staying at home or moving elsewhere.

Theou O, Tan EC, Bell JS, Emery T, Robson L, Morley JE, Rockwood K, Visvanathan R. Frailty Levels in Residential Aged Care Facilities Measured Using the Frailty Index and FRAIL-NH Scale. J Am Geriatr Soc. 2016 Nov;64(11):e207-e212. doi: 10.1111/jgs.14490. Epub 2016 Oct 26.

Abstract: OBJECTIVES: To compare the FRAIL-NH scale with the Frailty Index in assessing frailty in six Australian residential aged care facilities in individuals aged 65 and older. Frailty was assessed using the 66-item Frailty Index and the FRAIL-NH scale. Other measures examined were dementia diagnosis, level of care, resident satisfaction with care, nurse-reported resident quality of life, neuropsychiatric symptoms, and professional caregiver burden. CONCLUSION:The FRAIL-NH scale is a simple and practical method to screen for frailty in residential aged care facilities.

Moorhouse P, Mallery L, McNally M, Ellen R and Moffatt H. Frailty: It’s Time to Give Family Caregivers a Real Seat at the Table. J Fam Med. 2016; 3(5): 1067.

Abstract: The functional impact of lifelong accumulation of health issues (known as frailty), creates several challenges to traditional approaches to care planning and decision-making. In particular, the role of the caregiver (often a family member) in supporting the frail adult's needs is often at odds with how clinicians and teams approach " patient-centered care ". As the prevalence of frailty continues to increase, we need to embrace new approaches that widen the circle of care to include the caregiver more prominently in the provision of information and a more nuanced approach to shared decision-making.

Osman O, Sherifali D, Stolee P, Heckman GDiabetes Management in Long-Term Care: An Exploratory Study of the Current Practices and Processes to Managing Frail Elderly Persons with Type 2 Diabetes. Canadian Journal of Diabetes 40 (2016): 17-30.

Abstract: There is limited evidence for the management of diabetes in frail elderly residents living in long-term care (LTC) settings. The purpose of this study was to explore the current practices of glycemic management in frail elderly persons with diabetes living in LTC settings. The findings of this study were triangulated with both a quantitative survey and qualitative interviews. The implications of these findings suggest a disparity between what physicians feel should be achieved for diabetes management and what is actually done for frail elderly adults in LTC settings. Further research needs to be completed to assess the distinct needs and considerations of this unique population and healthcare setting.

Daniel I. McIsaac, Monica Taljaard, Gregory L. Bryson, Paul E. Beaule, Sylvain Gagne, Gavin Hamilton, Emily Hladkowicz, Allen Huang, John Joanisse, Luke T. Lavallée, Hussein Moloo, Kednapa Thavorn, Carl van Walraven, Homer Yang and Alan J. Forster. Comparative assessment of two frailty instruments for risk-stratification in elderly surgical patients: study protocol for a prospective cohort study. BMC Anesthesiology. 2016:16:111.DOI: 10.1186/s12871-016-0276-0

Click here to learn more about this CFN-funded research (FRA2015B-06).

Abstract: Frailty is an aggregate expression of susceptibility to poor outcomes, owing to age-, and disease-related deficits that accumulate within multiple domains. Older patients who are frail before surgery are at an increased risk of morbidity and mortality, and use a disproportionately high amount of healthcare resources. While frailty is now a well-established risk factor for adverse postoperative outcomes, the perioperative literature lacks studies that: 1) compare the predictive accuracy of different frailty instruments; 2) consider the impact of frailty on patient-reported outcome measures; and 3) consider the acceptability and feasibility of using frailty instruments in clinical practice.

Tom Noseworthy, Lesley Soril and Fiona Clement. Bioethics, health technology reassessment, and management. Healthcare Management Forum. 2016: 29(6): 275.

Abstract: Health Technology Reassessment (HTR) is an emerging area of health services and policy research that supports optimal management of technologies throughout their lifecycle. As a structured, evidence-based assessment of the clinical, economic, social, and ethical impacts of existing technologies, HTR is a means of achieving optimal use, managed exit, and better value for money from technologies used in healthcare. This has been documented as raising ethical concerns among clinicians who are providing direct patient care, particularly when managed exit may be the goal. This article discusses the ethical considerations relevant to clinicians and HTR, using a principles’ approach to bioethical decision-making.

Canadian Frailty Network. Brief to the federal Finance Committee 2017 pre-budget consultations. Click here to read our submission -- Ensuring a more equitable healthcare system: addressing the needs of Canada’s frail elderly.

We believe that frailty should be incorporated into federal healthcare funding models, and that by implementing frailty assessment in the healthcare system and producing evidence-based interventions and practices, true socioeconomic benefit to Canadians will result including improved quality of life and more efficient healthcare resource utilization.

Kho ME, Molloy AJ, Clarke F, Herridge MS, Koo KKY, Rudkowski J, Seely AJE, Pellizzari JR, Tarride JE, Mourtzakis M, Karachi T, Cook DJ, Canadian Clinical Trials Group. CYCLE pilot: a protocol for a pilot randomised study of early cycle ergometry versus routine physiotherapy in mechanically ventilated patients. BMJ Open 2016;6:
e011659. doi:10.1136/bmjopen-2016-011659 

Click here to learn more about this CFN-funded research (CAT2014-06).

Abstract: Early exercise with in-bed cycling as part of an intensive care unit (ICU) rehabilitation programme has the potential to improve physical and functional outcomes following critical illness. The objective of this study is to determine the feasibility of enrolling adults in a multicentre pilot randomised clinical trial (RCT) of early in-bed cycling versus routine physiotherapy to inform a larger RCT.

Cesari M, Marzetti E, Thiem U, Pérez-Zepeda MU, Van Kan GA, Landi F, Petrovic M, Cherubini A, Bernabei R. The geriatric management of frailty as paradigm of “The end of the disease era”. European Journal of Internal Medicine. 2016 June;31;11-14.DOI:

Abstract: The sustainability of healthcare systems worldwide is threatened by the absolute and relative increase in the number of older persons. The traditional models of care (largely based on a disease-centered approach) are inadequate for a clinical world dominated by older individuals with multiple (chronic) comorbidities and mutually interacting syndromes. There is the need to shift the center of the medical intervention from the disease to the biological age of the individual. Thus, multiple medical specialties have started looking with some interest at concepts of geriatric medicine in order to better face the increased complexity (due to age-related conditions) of their average patient. In this scenario, special interest has been given to frailty, a condition characterized by the reduction of the individual's homeostatic reserves and increased vulnerability to stressors. Frailty may indeed represent the fulcrum to lever for reshaping the healthcare systems in order to make them more responsive to new clinical needs. However, the dissemination of the frailty concept across medical specialties requires a parallel and careful consideration around the currently undervalued role of geriatricians in our daily practice.

Henrich NJ, Dodek PM, Alden L, Keenan SP, Reynolds S, Rodney P. Causes of moral distress in the intensive care unit: A qualitative study. J Crit Care. 2016 Oct;35:57-62. doi: 10.1016/j.jcrc.2016.04.033. Epub 2016 May 12.

Abstract: The purpose of the study was to examine the causes of moral distress in diverse members of the intensive care unit (ICU) team in both community and tertiary ICUs. Focus groups and coding of transcripts into themes and subthemes in 2 tertiary care ICUs and 1 community ICU were used. The most commonly reported causes of moral distress were concerns about the care provided by other health care workers, the amount of care provided (especially too much care at end of life), poor communication, inconsistent care plans, and issues around end of life decision making.Causes of moral distress vary among ICU professional groups, but all are amenable to improvement.

Muscedere J, Andrew MK, Bagshaw SM, Estabrooks C, Hogan D, Holroyd-Leduc J, Howlett S, Lahey W, Maxwell C, McNally M, Moorhouse P, Rockwood K, Rolfson D, Sinha S, Tholl B. Screening for Frailty in Canada's Health Care System: A Time for Action. Canadian Journal on Aging. 2016 Sept; 35(3):281-297. doi: 10.1017/S0714980816000301. Epub 2016 May 23.

Click here to learn more about CFN's National Frailty Forum and further work regarding the implications of frailty assessment.

Abstract: As Canada’s population ages, frailty – with its increased risk of functional decline, deterioration in health status, and death – will become increasingly common. The physiology of frailty reflects its multisystem, multi-organ origins. About a quarter of Canadians over age 65 are frail, increasing to over half in those older than 85. Our health care system is organized around single-organ systems, impairing our ability to effectively treat people having multiple disorders and functional limitations. To address frailty, we must recognize when it occurs, increase awareness of its significance, develop holistic models of care, and generate better evidence for its treatment. Recognizing how frailty impacts lifespan will allow for integration of care goals into treatment options. Different settings in the Canadian health care system will require different strategies and tools to assess frailty. Given the magnitude of challenges frailty poses for the health care system as currently organized, policy changes will be essential.

Heckman GA, Braceland B. Integrating Frailty Assessment Into Cardiovascular Decision Making. Canadian Journal of Cardiology. Volume 32, Issue 2, February 2016, Pages 139–141.

Abstract: Atrial fibrillation (AF) is the most common tachyarrhythmia, affecting > 1% of the population. Like most cardiovascular conditions, its prevalence increases with age, and the lifetime risk approaches 25%. The most feared complication of AF is stroke: AF accounts for approximately 20% of ischemic strokes, which are generally more severe and associated with greater disability and mortality. Furthermore, in the context of population aging, emerging data suggest that a strong association also exists between AF and the development of 2 important geriatric syndromes: dementia and frailty.